Köhler and Milstein fused B cells with cancer to mass-produce monoclonal antibodies
In 1975 Köhler and Milstein fused short-lived antibody-making cells with immortal myeloma cells, creating hybridomas — antibody factories that never die.
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1,000 CASOS PUBLICADOS · ATUALIZADOS REGULARMENTEKochi Water Metro ran island ferries like a metro: 6.5 million riders in 3 years
India's first water metro put metro-rail discipline — schedules, shared fares, terminals — onto Kerala's backwaters in battery-electric boats.
Ler o casoKBO got its first exact playoff math when a Mines team rebuilt magic numbers for draws
Mines researchers adapted MLB clinch models to Korean baseball's draw rule during COVID, giving Korean fans math their media never had.
Ler o casoKavach: India wrote its own train-protection spec and licensed it to rival vendors
First trialled in 2016, the SIL-4 automatic train protection system is now commissioned on 2,569 route km, built by competing Indian OEMs at Rs 50 lakh per km.
Ler o casoKaplan and Meier turned censored follow-ups into the survival curve doctors read today
The 1958 product-limit estimator counts every patient only while visible, so dropouts stop being missing data and survival became computable from messy trials.
Ler o casoKALAHI-CIDSS let Philippine villages fund, rank and build their own projects
The Philippines gave poor villages block grants and had them rank each other's proposals in open forums — 8,600 community projects, +12% consumption.
Ler o casoIreland stopped capping wind and started buying flexibility — 50% to 75%
EirGrid turned grid stability into purchasable services, paid generators for flexibility, and pushed instantaneous renewables from 50% to 75% of demand.
Ler o casoImpulse put a 3kWh battery inside its cooktop so induction runs on a plain 120V outlet
Impulse Labs built a $6,000 induction cooktop with a built-in 3kWh battery that plugs into a standard 120V outlet and boils water in 30 seconds.
Ler o casoIchiran's solo booths turned ramen from a chef's craft into a private sensory test
A patented single-seat counter, paper order forms and a 15-second serve rule let one tonkotsu recipe sell customization, privacy and speed at once
Ler o casoThe 230-volt compromise: Europe harmonized its grid label, not its wires
In 1994 an IEC amendment made both Europe's 220 V and 240 V grids "230 V" via asymmetric tolerance bands — no rewiring, just wider fine print.
Ler o casoIceland quarantined its trapped money, drained it by auction, then opened the gates
To end eight years of capital controls without a stampede, Iceland segregated offshore krónur by law, drained exit demand by auction, then bought out the rest.
Ler o casoIBM's multiobjective DSS scored supply-chain reconfiguration on 22 considerations
IBM's spreadsheet-based multiattribute tool weighed cost, quality, responsiveness and strategy across five supply-chain decisions.
Ler o casoIBM's GMR read head let hard disks shrink into laptops and pocket players
Electron spin turned weak magnetic fields into big resistance swings — the 1997 read head that carried disks to terabytes and music into pockets.
Ler o casoHuitongda armed 80,000 village shops instead of replacing them
Huitongda signed township mom-and-pop stores as members, gave them B2B sourcing plus SaaS, and became Alibaba's $716M answer to rural China
Ler o casoHard Off made used goods trustworthy — clean stores, repair, searchable one-offs
Hard Off rebuilt Japan's junk trade as a clean, repaired, fixed-price chain, kept every store idiosyncratic, and now lists each store's one-offs on Google
Ler o casoHamazushi removed rotating lanes from 90% of stores, cutting 1,000 tons of waste a year
The Zensho sushi chain swapped endless belts for order-to-seat straight lanes, solving hygiene, food waste and demand mismatch in one store redesign.
Ler o casoHallmark inventory managers adopted a payoff-matrix newsboy model for run sizes
Hallmark taught inventory managers to size runs with a newsboy payoff matrix, and model-based decisions beat business as usual on parallel tests.
Ler o casoGyandoot: Dhar's village kiosks sold government services at ₹10 a transaction
A collector's intranet put kiosks in market towns, each run by a self-financed operator earning ₹10 a service — government access that paid its own way.
Ler o casoGrupo Mateus restocks 300+ Amazon-region stores over a 2,700-km rail spine
Brazil's distance problem solved at home: supplier freight rides the Norte-Sul railway for the middle 2,400 km; trucks only touch pickup and last mile.
Ler o casoGoodme dominated small cities and cold-chain-delivered them fresh milk twice a week
While rivals fought over Shanghai, Goodme saturated tier-3/4 cities and built its own cold chain so township shops could pour fresh fruit and fresh milk.
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