Köhler and Milstein fused B cells with cancer to mass-produce monoclonal antibodies
In 1975 Köhler and Milstein fused short-lived antibody-making cells with immortal myeloma cells, creating hybridomas — antibody factories that never die.
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1,000 CAS PUBLIÉS · MIS À JOUR RÉGULIÈREMENTKochi Water Metro ran island ferries like a metro: 6.5 million riders in 3 years
India's first water metro put metro-rail discipline — schedules, shared fares, terminals — onto Kerala's backwaters in battery-electric boats.
Lire le casKBO got its first exact playoff math when a Mines team rebuilt magic numbers for draws
Mines researchers adapted MLB clinch models to Korean baseball's draw rule during COVID, giving Korean fans math their media never had.
Lire le casKavach: India wrote its own train-protection spec and licensed it to rival vendors
First trialled in 2016, the SIL-4 automatic train protection system is now commissioned on 2,569 route km, built by competing Indian OEMs at Rs 50 lakh per km.
Lire le casKaplan and Meier turned censored follow-ups into the survival curve doctors read today
The 1958 product-limit estimator counts every patient only while visible, so dropouts stop being missing data and survival became computable from messy trials.
Lire le casKALAHI-CIDSS let Philippine villages fund, rank and build their own projects
The Philippines gave poor villages block grants and had them rank each other's proposals in open forums — 8,600 community projects, +12% consumption.
Lire le casIreland stopped capping wind and started buying flexibility — 50% to 75%
EirGrid turned grid stability into purchasable services, paid generators for flexibility, and pushed instantaneous renewables from 50% to 75% of demand.
Lire le casImpulse put a 3kWh battery inside its cooktop so induction runs on a plain 120V outlet
Impulse Labs built a $6,000 induction cooktop with a built-in 3kWh battery that plugs into a standard 120V outlet and boils water in 30 seconds.
Lire le casIchiran's solo booths turned ramen from a chef's craft into a private sensory test
A patented single-seat counter, paper order forms and a 15-second serve rule let one tonkotsu recipe sell customization, privacy and speed at once
Lire le casThe 230-volt compromise: Europe harmonized its grid label, not its wires
In 1994 an IEC amendment made both Europe's 220 V and 240 V grids "230 V" via asymmetric tolerance bands — no rewiring, just wider fine print.
Lire le casIceland quarantined its trapped money, drained it by auction, then opened the gates
To end eight years of capital controls without a stampede, Iceland segregated offshore krónur by law, drained exit demand by auction, then bought out the rest.
Lire le casIBM's multiobjective DSS scored supply-chain reconfiguration on 22 considerations
IBM's spreadsheet-based multiattribute tool weighed cost, quality, responsiveness and strategy across five supply-chain decisions.
Lire le casIBM's GMR read head let hard disks shrink into laptops and pocket players
Electron spin turned weak magnetic fields into big resistance swings — the 1997 read head that carried disks to terabytes and music into pockets.
Lire le casHuitongda armed 80,000 village shops instead of replacing them
Huitongda signed township mom-and-pop stores as members, gave them B2B sourcing plus SaaS, and became Alibaba's $716M answer to rural China
Lire le casHard Off made used goods trustworthy — clean stores, repair, searchable one-offs
Hard Off rebuilt Japan's junk trade as a clean, repaired, fixed-price chain, kept every store idiosyncratic, and now lists each store's one-offs on Google
Lire le casHamazushi removed rotating lanes from 90% of stores, cutting 1,000 tons of waste a year
The Zensho sushi chain swapped endless belts for order-to-seat straight lanes, solving hygiene, food waste and demand mismatch in one store redesign.
Lire le casHallmark inventory managers adopted a payoff-matrix newsboy model for run sizes
Hallmark taught inventory managers to size runs with a newsboy payoff matrix, and model-based decisions beat business as usual on parallel tests.
Lire le casGyandoot: Dhar's village kiosks sold government services at ₹10 a transaction
A collector's intranet put kiosks in market towns, each run by a self-financed operator earning ₹10 a service — government access that paid its own way.
Lire le casGrupo Mateus restocks 300+ Amazon-region stores over a 2,700-km rail spine
Brazil's distance problem solved at home: supplier freight rides the Norte-Sul railway for the middle 2,400 km; trucks only touch pickup and last mile.
Lire le casGoodme dominated small cities and cold-chain-delivered them fresh milk twice a week
While rivals fought over Shanghai, Goodme saturated tier-3/4 cities and built its own cold chain so township shops could pour fresh fruit and fresh milk.
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